De Novo Donor-Specific Antibodies after Heart Transplantation: A Comprehensive Guide for Clinicians
Irene Marco, Juan Carlos López-Azor García, Javier González Martín, Andrea Severo Sánchez, María Dolores García-Cosío Carmena, Esther Mancebo Sierra, Javier de Juan Bagudá, Javier Castrodeza Calvo, Francisco José Hernández Pérez, Juan Francisco Delgado, Teruhiko Imamura, Jürgen R Sindermann · 2023
Read De Novo Donor-Specific Antibodies after Heart Transplantation: A Comprehensive Guide for Clinicians by Irene Marco, Juan Carlos López-Azor García, Javier González Martín, Andrea Severo Sánchez, María Dolores García-Cosío Carmena, Esther Mancebo Sierra, Javier de Juan Bagudá, Javier Castrodeza Calvo, Francisco José Hernández Pérez, Juan Francisco Delgado, Teruhiko Imamura, Jürgen R Sindermann (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10707043.txt.
Description
Irene Marco and a large clinical team write a practical guide to a warning signal after heart transplantation, in a paper published in 2023. Some recipients develop new antibodies aimed at the donor's tissue markers. These antibodies are tied to vessel disease in the graft, rejection, and death, and modern tests find them more often, yet clinics disagree on what to do when they appear.
The guide weighs which antibodies are most dangerous: those against class II markers, especially DQ, ones that bind complement, and ones that persist. Because damage may be irreversible by the time failure shows, the authors lean toward earlier, stronger action, using heart imaging and vessel tests to spot silent injury. Standard treatments include plasma exchange, immunoglobulin, and rituximab, though their benefit is still debated.
Catalog record
| CREATOR | Irene Marco, Juan Carlos López-Azor García, Javier González Martín, Andrea Severo Sánchez, María Dolores García-Cosío Carmena, Esther Mancebo Sierra, Javier de Juan Bagudá, Javier Castrodeza Calvo, Francisco José Hernández Pérez, Juan Francisco Delgado, Teruhiko Imamura, Jürgen R Sindermann |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |