Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer’s Disease
Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto, Alberto Pérez-Mediavilla · 2023
Read Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer’s Disease by Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto, Alberto Pérez-Mediavilla (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10706894.txt.
Description
Santiago Ramirez and co-authors test, in a 2023 study, whether swapping out blood plasma can slow Alzheimer's disease in mice. The idea rests on balance. The protein amyloid-beta builds up in the brain partly because its level in blood is out of tune. Clearing the blood may then draw it out of the brain.
Mice bred to develop the disease received monthly plasma exchange with an albumin solution from three to seven months of age. Treated mice ended with less of the protein in blood and in the solid brain fraction. Brain slices showed fewer plaques in memory regions, smaller plaque size spread, and fewer reactive support cells.
Catalog record
| CREATOR | Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto, Alberto Pérez-Mediavilla |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |