Pan-Cancer Profiling of Intron Retention and Its Clinical Significance in Diagnosis and Prognosis
Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, Ting Ni · 2023
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Description
When a gene's message is copied, spare sections called introns are usually snipped out, but sometimes one is kept in, and that choice can matter in cancer. Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, and Ting Ni mapped these kept introns across more than ten thousand tumor samples from thirty-three cancer types. They compared tumors with healthy tissue and checked which kept introns track with patient survival.
They found nine hundred and eighty-eight kept introns that differ across fourteen cancers, some useful for spotting the disease. One case stood out: a kept intron in a gene called STN1 slowed lung cancer cells in the lab and tracked with better survival. The team says such patterns could serve as markers or drug targets.
Catalog record
| CREATOR | Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, Ting Ni |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |