Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer
Kang Yao, Zhu Xiaojun, Zhao Tingxiao, Liao Shiyao, Ji Lichen, Zhang Wei, Li Yanlei, Tian Jinlong, Ding Xiaoyan, Zhang Jun, Bi Qing, Lv Jun · 2023
Read Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer by Kang Yao, Zhu Xiaojun, Zhao Tingxiao, Liao Shiyao, Ji Lichen, Zhang Wei, Li Yanlei, Tian Jinlong, Ding Xiaoyan, Zhang Jun, Bi Qing, Lv Jun (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10704724.txt.
Description
Kang Yao and co-authors trace how breast cancer spreads to bone, with focus on support cells in the tumour, in work from twenty twenty-three. Breast cancer often spreads far, and bone is a favoured site. The team mines several public cohorts to find molecules tied to bone spread. Lab tests then check how those molecules act in cancer cells. Movement, growth, and invasion assays cover the main checks.
Six molecules track with patient outlook and sit mostly in support cells called CAFs. Those support cells switch on many cancer growth paths at once. They also trade signals with cancer, vessel, and immune cells nearby. In that way they reshape the tumour setting and boost bad cell behaviour. One molecule, MMP13, is picked for deeper study. Raising it makes cancer cells act more aggressively in the lab. Immune entry patterns around it are also mapped.
Catalog record
| CREATOR | Kang Yao, Zhu Xiaojun, Zhao Tingxiao, Liao Shiyao, Ji Lichen, Zhang Wei, Li Yanlei, Tian Jinlong, Ding Xiaoyan, Zhang Jun, Bi Qing, Lv Jun |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |