Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Wen Fan, Chong Liu, Dacai Chen, Chenjie Xu, Xiuting Qi, Ailin Zhang, Xuexian Zhu, Yujie Liu, Lei Wang, Lanxiang Hao, Wen-Tao Liu, Liang Hu · 2023
Read Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway by Wen Fan, Chong Liu, Dacai Chen, Chenjie Xu, Xiuting Qi, Ailin Zhang, Xuexian Zhu, Yujie Liu, Lei Wang, Lanxiang Hao, Wen-Tao Liu, Liang Hu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10704676.txt.
Description
Wen Fan and eleven co-authors show ozone gas easing gout pain in mice in a 2023 study. Gout flares ride on joint swelling, and care still lacks a strong answer. Ozone is used in some pain clinics, but its inner path was murky. The team gave ozone to gouty mice and traced the signal chain it wakes.
Ozone cut joint swelling, eased pain, and steadied the mice's gait. It switched on an energy sensor that raised a scout protein, Gas6, which in turn fired a calming chain in immune cells and curbed a tissue chewing enzyme. Blocking the sensor or the chain erased ozone's gains, and mice born without Gas6 lost the benefit too. Human blood reads fit the frame. The authors name the chain as ozone's route.
Catalog record
| CREATOR | Wen Fan, Chong Liu, Dacai Chen, Chenjie Xu, Xiuting Qi, Ailin Zhang, Xuexian Zhu, Yujie Liu, Lei Wang, Lanxiang Hao, Wen-Tao Liu, Liang Hu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |