Clinical features of acute attacks, chronic symptoms, and long-term complications among patients with acute hepatic porphyria in Japan: a real-world claims database study
Yutaka Horie, Yuka Yasuoka, Tomohide Adachi · 2023
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Description
Yutaka Horie, Yuka Yasuoka, and Tomohide Adachi chart the burden of acute hepatic porphyria in Japan, in a 2023 study. This family of rare genetic diseases strikes in sudden attacks and can leave lasting damage. The team used a large Japanese claims database covering 2008 to 2020. Patients were matched by age and sex to people without the disease for comparison.
Just under four hundred patients were included. About eighteen percent had one attack during the window, and about ten percent had two or more. Chronic complaints like sleep problems, stress disorders, belly pain, and nausea ran well above matched rates. Long-term harms included liver scarring and cancer, kidney failure, nerve damage, and high blood pressure. Older patients showed the same heavy pattern. The study gives Japan a real-world map of this rare disease.
Catalog record
| CREATOR | Yutaka Horie, Yuka Yasuoka, Tomohide Adachi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |