Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
J. McClatchy, R. Strogantsev, E. Wolfe, H. Y. Lin, M. Mohammadhosseini, B. A. Davis, C. Eden, D. Goldman, W. H. Fleming, P. Conley, G. Wu, L. Cimmino, H. Mohammed, A. Agarwal · 2023
Read Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells by J. McClatchy, R. Strogantsev, E. Wolfe, H. Y. Lin, M. Mohammadhosseini, B. A. Davis, C. Eden, D. Goldman, W. H. Fleming, P. Conley, G. Wu, L. Cimmino, H. Mohammed, A. Agarwal (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10703894.txt.
Description
J McClatchy and co-authors study a gene fault that blocks a swelling signal's cell reset in blood stem cells in a 2023 paper. The fault grows from one stem cell that gains an edge and clones. Such clones raise risk of blood cancer and heart disease in those who bear them.
The swelling signal is high in bearers, yet its work was vague. In a mouse form of the clone state, the signal grew a clan of hot defence cells. At the same time, gene tags that should clear for blood line growth stayed shut.
Catalog record
| CREATOR | J. McClatchy, R. Strogantsev, E. Wolfe, H. Y. Lin, M. Mohammadhosseini, B. A. Davis, C. Eden, D. Goldman, W. H. Fleming, P. Conley, G. Wu, L. Cimmino, H. Mohammed, A. Agarwal |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |