Investigating the impact of paternal aging on murine sperm miRNA profiles and their potential link to autism spectrum disorder
Kazusa Miyahara, Misako Tatehana, Takako Kikkawa, Noriko Osumi · 2023
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Description
Kazusa Miyahara, Misako Tatehana, Takako Kikkawa, and Noriko Osumi report a two thousand twenty-three mouse study on father's age and sperm. Older fathers link to higher autism risk in children. Tiny RNA molecules in sperm may carry age effects.
The team profiled sperm microRNAs from mice at three ages. Dozens of molecules changed between young and old groups. Their target genes clustered around cell death pathways and the nervous system. The pattern suggests ageing sperm could pass risk signals to offspring. Readers get a possible biological route behind a well-known statistical link.
Catalog record
| CREATOR | Kazusa Miyahara, Misako Tatehana, Takako Kikkawa, Noriko Osumi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |