Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum
Kazuhiro Yamanoi, Chifumi Fujii, Atsushi Nakayama, Noriko Matsuura, Yusaku Takatori, Motohiko Kato, Naohisa Yahagi, Jun Nakayama · 2023
Read Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum by Kazuhiro Yamanoi, Chifumi Fujii, Atsushi Nakayama, Noriko Matsuura, Yusaku Takatori, Motohiko Kato, Naohisa Yahagi, Jun Nakayama (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10703765.txt.
Description
Kazuhiro Yamanoi and co-authors hunt, in a 2023 study, for warning signs that a rare duodenal growth is turning cancerous. Pyloric gland adenomas grow in the first stretch of the small intestine and often harbor high-grade change. Healthy glands of this type coat their mucus with a sugar tag and release a small partner peptide. The sugar tag is known to hold back stomach tumors, but the peptide's role was unclear.
The team stained twenty lesions, both low and high grade, for the tag, the peptide, and related markers. Low-grade growths showed both tag and peptide alongside the mucus protein. High-grade growths kept the mucus protein but lost much of the tag and peptide. That loss tracked closely with the more dangerous cell changes. The authors propose both drops as markers of malignant potential in these tumors.
Catalog record
| CREATOR | Kazuhiro Yamanoi, Chifumi Fujii, Atsushi Nakayama, Noriko Matsuura, Yusaku Takatori, Motohiko Kato, Naohisa Yahagi, Jun Nakayama |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |