Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy
Sacha Ichbiah, Fabrice Delbary, Alex McDougall, Rémi Dumollard, Hervé Turlier · 2023
Read Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy by Sacha Ichbiah, Fabrice Delbary, Alex McDougall, Rémi Dumollard, Hervé Turlier (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10703677.txt.
Description
Ichbiah, Delbary, McDougall, Dumollard, and Turlier present in twenty twenty-three a way to map forces inside developing embryos from microscope images. Genes in embryos can now be mapped cell by cell over time, but forces could not. Because embryo cells pack like foam, the team built a method that reads cell shapes from membrane images and infers each cell's surface tension and pressure in three dimensions.
They checked the method on simulated foams, tested its noise tolerance, and applied it to mouse, sea squirt, and worm embryos. It recovered known mechanical features and predicted new ones. The code is freely available. The authors hope force atlases will reveal how mechanics and chemistry steer growth together.
Catalog record
| CREATOR | Sacha Ichbiah, Fabrice Delbary, Alex McDougall, Rémi Dumollard, Hervé Turlier |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |