Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases
Jindong Xie, Wei Deng, Xinpei Deng, Jie-Ying Liang, Yuhui Tang, Jun Huang, Hailin Tang, Yutian Zou, Huamao Zhou, Xiaoming Xie · 2023
Read Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases by Jindong Xie, Wei Deng, Xinpei Deng, Jie-Ying Liang, Yuhui Tang, Jun Huang, Hailin Tang, Yutian Zou, Huamao Zhou, Xiaoming Xie (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10702093.txt.
Description
Jindong Xie and co-authors map helper proteins that guard DNA packaging inside breast cancer cells and their surroundings, in a study from 2023. These proteins, called histone chaperones, keep the genome stable and steer gene activity in many cancers. What they do inside a tumor's mixed cell community was unclear.
The team reanalyzed single cell gene data from six patients whose cancer had spread to brain or liver. Patterns across thirty six chaperones sorted the tumor's cells, including immune and support cells, into subgroups. Those patterns were then checked in larger public cohorts for links to survival and response to immune therapy. One chaperone, HSPA8, was tested in lab assays of cell movement and invasion. The work ties these guardian proteins to spread of the disease.
Catalog record
| CREATOR | Jindong Xie, Wei Deng, Xinpei Deng, Jie-Ying Liang, Yuhui Tang, Jun Huang, Hailin Tang, Yutian Zou, Huamao Zhou, Xiaoming Xie |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |