Fatty acid binding protein type 7 deficiency preserves auditory function in noise-exposed mice

Jun Suzuki, Tomotaka Hemmi, Masamitsu Maekawa, Masahiro Watanabe, Hitoshi Inada, Hiroyuki Ikushima, Tetsuya Oishi, Ryoukichi Ikeda, Yohei Honkura, Yoshiteru Kagawa, Tetsuaki Kawase, Nariyasu Mano, Yuji Owada, Noriko Osumi, Yukio Katori · 2023

Read Fatty acid binding protein type 7 deficiency preserves auditory function in noise-exposed mice by Jun Suzuki, Tomotaka Hemmi, Masamitsu Maekawa, Masahiro Watanabe, Hitoshi Inada, Hiroyuki Ikushima, Tetsuya Oishi, Ryoukichi Ikeda, Yohei Honkura, Yoshiteru Kagawa, Tetsuaki Kawase, Nariyasu Mano, Yuji Owada, Noriko Osumi, Yukio Katori (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10700610.txt.

Description

Jun Suzuki and fourteen co-authors present a 2023 study of a fat handling protein and noise caused hearing loss in mice. The protein helps cells take in and move fatty acids in the nervous system. Whether it shapes the ear's response to loud noise was unknown.

The team bred mice that lack the protein and compared their hearing with normal mice. Hearing was tested before noise, a day after a loud blast, and two weeks later. At the start, the groups heard alike. After noise, the mice without the protein kept lower hearing thresholds and more of their sound sensing cells survived. Gene and chemical readouts from the inner ear filled in the picture.

Catalog record

CREATORJun Suzuki, Tomotaka Hemmi, Masamitsu Maekawa, Masahiro Watanabe, Hitoshi Inada, Hiroyuki Ikushima, Tetsuya Oishi, Ryoukichi Ikeda, Yohei Honkura, Yoshiteru Kagawa, Tetsuaki Kawase, Nariyasu Mano, Yuji Owada, Noriko Osumi, Yukio Katori
YEAR2023
COLLECTIONPAPERS
FORMATTXT
FILE SIZE50 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC10700610

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