Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB
Rui-Meng Yang, Shi-Yang Song, Feng-Yao Wu, Rui-Feng Yang, Yan-Ting Shen, Ping-Hui Tu, Zheng Wang, Jun-Xiu Zhang, Feng Cheng, Guan-Qi Gao, Jun Liang, Miao-Miao Guo, Liu Yang, Yi Zhou, Shuang-Xia Zhao, Ming Zhan, Huai-Dong Song · 2023
Read Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB by Rui-Meng Yang, Shi-Yang Song, Feng-Yao Wu, Rui-Feng Yang, Yan-Ting Shen, Ping-Hui Tu, Zheng Wang, Jun-Xiu Zhang, Feng Cheng, Guan-Qi Gao, Jun Liang, Miao-Miao Guo, Liu Yang, Yi Zhou, Shuang-Xia Zhao, Ming Zhan, Huai-Dong Song (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10700497.txt.
Description
Rui-Meng Yang and a large team study how the thyroid gland builds its working units, in this 2023 paper. The gland is made of tiny balls called follicles, and faults in their making cause thyroid dysgenesis, a cause of low thyroid function from birth. How thyroid cells move out and form new follicles was not well understood.
Using single-cell and spatial gene maps in mice, the team found a group of thyroid cells at the gland's center with an active NF-κB switch and a partly loose, mobile character. Traced in zebrafish, these cells pushed out and seeded new follicles. Blocking the switch stalled their movement and mimicked the disease. Immune cells of the myeloid type helped by touching the cells and releasing a signal, TNF-α. Fish lacking myeloid cells showed the same movement fault.
Catalog record
| CREATOR | Rui-Meng Yang, Shi-Yang Song, Feng-Yao Wu, Rui-Feng Yang, Yan-Ting Shen, Ping-Hui Tu, Zheng Wang, Jun-Xiu Zhang, Feng Cheng, Guan-Qi Gao, Jun Liang, Miao-Miao Guo, Liu Yang, Yi Zhou, Shuang-Xia Zhao, Ming Zhan, Huai-Dong Song |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |