Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia
Kevin E McElhanon, Tyler C Huff, Dinesh Hirenallur-Shanthappa, Russell A Miller, Nicolas Christoforou · 2023
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Description
Kevin McElhanon and co-authors test whether high blood progranulin causes heart rhythm trouble in this 2023 paper. Atrial fibrillation rises alongside obesity, and blood proteins may carry part of that risk. Progranulin was a candidate from that overlap. A virus vector raised its level in mouse blood for twenty weeks.
Heart tracings ran with and without a stimulant challenge. Ultrasound measured heart structure and pumping after the exposure. Extra progranulin alone did not produce rhythm faults or weaken the heart in this setup. The negative answer matters, since it prunes a plausible suspect. Obesity linked fibrillation must run through other messengers. Careful negative studies keep drug programs from chasing ghosts.
Catalog record
| CREATOR | Kevin E McElhanon, Tyler C Huff, Dinesh Hirenallur-Shanthappa, Russell A Miller, Nicolas Christoforou |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |