Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level
Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristopher Sarosiek, Hidemi Fujino, Christopher L-H Huang, Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristophe · 2023
Read Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level by Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristopher Sarosiek, Hidemi Fujino, Christopher L-H Huang, Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristophe (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10699803.txt.
Description
Atomu Yamaguchi and co-authors show in 2023 that pulsed ultrasound makes muscle tubes release more tiny packets with anti inflammatory effects. Muscle is the largest organ in the body and sends out signals that calm immune cells called macrophages. Those signals can ride in extracellular vesicles, small bubbles shed by cells that are gaining interest as therapy carriers.
Strong ultrasound raised vesicle release from mouse muscle cells by lifting calcium inside the cells, with no harm seen. Vesicles released this way lowered pro inflammatory factors in macrophages. RNA profiling found two small RNAs especially rich in muscle vesicles. The authors argue that a physical push like ultrasound could help harvest calming vesicles from muscle for use against inflamed or failing tissues, though the work stays in cell culture.
Catalog record
| CREATOR | Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristopher Sarosiek, Hidemi Fujino, Christopher L-H Huang, Atomu Yamaguchi, Noriaki Maeshige, Hikari Noguchi, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Dongming Su, Hiroyo Kondo, Kristophe |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |