Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Wenhua Wang, Huaihuai Peng, Menghao Zeng, Jie Liu, Guibin Liang, Zhihui He · 2023
Read Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease by Wenhua Wang, Huaihuai Peng, Menghao Zeng, Jie Liu, Guibin Liang, Zhihui He (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10699081.txt.
Description
Wenhua Wang and co-authors test a cell therapy in mice in this 2023 study of chronic lung disease. The disease harms the lungs and ages organs across the body, and current drugs help only a little. Young vessel-lining starter cells may slow that aging, so the team gives them through a vein to mice raised on smoke.
After treatment, aging marks fell in the lung, heart, liver, spleen, and kidney of the mice. Genes tied to cell growth and life span rose, while a key aging gene fell. Two partner proteins in one aging path also dropped across organs. The shape of the tissues, though, did not return to normal. The authors see the cell route as a hopeful path that needs more work.
Catalog record
| CREATOR | Wenhua Wang, Huaihuai Peng, Menghao Zeng, Jie Liu, Guibin Liang, Zhihui He |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |