Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors
Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Linda Dainese, Arnauld Verschuur, Benoit Dumont, Roger Mouawad, Li Xu, Wenxuan Cheng, Fangrong Yan, Sabine Irtan, Véronique Lindner, Catherine Paillard, Yves Le Bouc, Aurore Coulomb, Gabriel G Malouf · 2023
Read Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors by Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Linda Dainese, Arnauld Verschuur, Benoit Dumont, Roger Mouawad, Li Xu, Wenxuan Cheng, Fangrong Yan, Sabine Irtan, Véronique Lindner, Catherine Paillard, Yves Le Bouc, Aurore Coulomb, Gabriel G Malouf (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10689851.txt.
Description
Xiaoping Su and fourteen co-authors chart a bleak subtype of childhood kidney cancer in a 2023 paper. Wilms tumors usually yield to treatment, but the diffuse anaplastic kind resists, and children die. Layered molecular profiling was the way to see why.
A third of these tumors formed a desert: few immune or support cells, a broken TP53 gene, and a silenced alarm pathway that should summon immunity. Drugs blocking two enzymes, one that edits DNA packaging and one that guards cell division, attacked the tumors in lab models. Better still, those drugs might wake the immune system to join the fight. The authors offer the subtype map for matching children to therapy.
Catalog record
| CREATOR | Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Linda Dainese, Arnauld Verschuur, Benoit Dumont, Roger Mouawad, Li Xu, Wenxuan Cheng, Fangrong Yan, Sabine Irtan, Véronique Lindner, Catherine Paillard, Yves Le Bouc, Aurore Coulomb, Gabriel G Malouf |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |