The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation
Johannes Benedum, Vedran Franke, Lisa-Marie Appel, Lena Walch, Melania Bruno, Rebecca Schneeweiss, Juliane Gruber, Helena Oberndorfer, Emma Frank, Xué Strobl, Anton Polyansky, Bojan Zagrovic, Altuna Akalin, Dea Slade · 2023
Read The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation by Johannes Benedum, Vedran Franke, Lisa-Marie Appel, Lena Walch, Melania Bruno, Rebecca Schneeweiss, Juliane Gruber, Helena Oberndorfer, Emma Frank, Xué Strobl, Anton Polyansky, Bojan Zagrovic, Altuna Akalin, Dea Slade (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10689479.txt.
Description
Johannes Benedum and co-authors study two sibling proteins that help control gene reading in a 2023 paper. The proteins, DIDO3 and PHF3, latch onto the cell's main transcription machine as it moves along a gene. Together they form a complex that links that machine with chromatin and with RNA processing factors, holding it in a droplet-like local zone.
The pair pull in partly shared, partly opposed ways. Both are needed for nerve cell development, and each controls a set of nerve genes. When PHF3 is missing, DIDO3 rises to compensate. DIDO alone also manages genes for fat metabolism. The authors describe a layered control system in which the two paralogues share, split, and back up each other's jobs.
Catalog record
| CREATOR | Johannes Benedum, Vedran Franke, Lisa-Marie Appel, Lena Walch, Melania Bruno, Rebecca Schneeweiss, Juliane Gruber, Helena Oberndorfer, Emma Frank, Xué Strobl, Anton Polyansky, Bojan Zagrovic, Altuna Akalin, Dea Slade |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |