Advances in understanding the mechanism of action of adult vaccines
Anthony L Cunningham, Kerrie J Sandgren, Naomi R Truong · 2023
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Description
Anthony Cunningham, Kerrie Sandgren, and Naomi Truong explain new findings on shingles vaccines in a 2023 paper. Shingles risk climbs as memory cells against the chickenpox virus fade with age, above all past fifty. A live vaccine aimed to restore those cells, yet a recombinant one proved stronger and longer-lasting.
Fresh work shows both vaccines wake naive helper cells, not just memory ones, against the key viral protein. The recombinant vaccine did so far more strongly, folding fresh recruits into lasting memory. That gap helps explain its edge. The lesson steers design of stronger vaccines for older adults.
Catalog record
| CREATOR | Anthony L Cunningham, Kerrie J Sandgren, Naomi R Truong |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |