An association between ATP7B expression and human cancer prognosis and immunotherapy: a pan-cancer perspective
Zhanzhan Zhang, Aobo Zhang, Yunpeng Shi, Zijun Zhao, Zongmao Zhao · 2023
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Description
Zhanzhan Zhang and co-authors scan every major cancer for the footprint of a copper-carrying protein in a 2023 study. ATP7B ferries copper inside cells, and cancer cells exploit it to shrug off chemotherapy. Its wider role across cancers, prognosis, immunity, and drug response had never been charted in one pass.
Mining two vast public atlases of tumor and healthy tissue, the team compared the protein's gene activity cancer by cancer. Expression split sharply between tumor and neighboring tissue. In two cancers, a brain tumor type and a kidney cancer, its level tracked patient survival. Immune cell infiltration, mutation burden, and checkpoint molecules each correlated with the gene in particular cancers, and drug sensitivity in cell lines followed its expression too. The authors nominate ATP7B as a candidate biomarker for prognosis and immunotherapy planning, pending the lab work such claims require.
Catalog record
| CREATOR | Zhanzhan Zhang, Aobo Zhang, Yunpeng Shi, Zijun Zhao, Zongmao Zhao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |