Circulating inflammatory cytokines and hypertensive disorders of pregnancy: a two-sample Mendelian randomization study
Siqi Guan, Xiaoxu Bai, Jincheng Ding, Rujin Zhuang · 2023
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Description
Siqi Guan and co-authors test whether inflammation signals cause hypertension in pregnancy in a 2023 gene study. Blood pressure disorders put mother and fetus at risk, and inflammation is deeply tied to them. A tie is not proof of cause, so the team used Mendelian randomization.
Gene variants stood in for lifelong levels of circulating cytokines. Four disorder types were checked, from new high blood pressure in pregnancy to pre-eclampsia layered on old high blood pressure. Five methods cross-checked the causal call, with the weighted one in the lead. Two signals, interleukin-9 and one migration factor, appeared to lower risk. Three others, including interleukins 13 and 16, appeared to raise it. The five are offered as leads on cause.
Catalog record
| CREATOR | Siqi Guan, Xiaoxu Bai, Jincheng Ding, Rujin Zhuang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |