Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2
Vamsi Krishna Gali, Chandre Monerawela, Yassine Laksir, Shin-ichiro Hiraga, Anne D. Donaldson · 2023
Read Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2 by Vamsi Krishna Gali, Chandre Monerawela, Yassine Laksir, Shin-ichiro Hiraga, Anne D. Donaldson (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10681312.txt.
Description
A peer-reviewed research article from Europe PMC (2023). In budding yeast the Rif1 protein is important for protecting nascent DNA at blocked replication forks, but the mechanism has been unclear. Here we show that budding yeast Rif1 must interact with Protein Phosphatase 1 to protect nascent DNA. In the absence of Rif1, removal of either Dna2 or Sgs1 prevents nascent DNA degradation, implying that Rif1 protects nascent DNA by targeting Protein Phosphatase 1 to oppose degradation by the Sgs1-Dna2 nuclease-helicase complex.
Catalog record
| CREATOR | Vamsi Krishna Gali, Chandre Monerawela, Yassine Laksir, Shin-ichiro Hiraga, Anne D. Donaldson |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |