Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations
Jorge Ederson Gonçalves Santana, Cícera Datiane de Morais Oliveira-Tintino, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Daniel Sampaio Alves, Talysson Felismino Moura, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, João Pedro Viana Rodrigues, Vanessa Barbosa Pinheiro Gonçalves, Robert · 2023
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Description
Jorge Santana and co-authors test plant scents against the pumps bacteria use to spit out antibiotics in a 2023 study. Efflux pumps are a prime resistance trick in Staphylococcus aureus. Three scent compounds from herbs and resins were tried free and wrapped in fat bubbles.
Four pump-carrying resistant strains faced the compounds alongside standard drugs. The scents lowered the dose of antibiotics and of a pump tracer needed to bite, showing the pumps were jammed. Liposome wrapping changed some effects for better or worse by compound. Natural pump blockers could rescue failing antibiotics, the authors argue, if delivery is tuned.
Catalog record
| CREATOR | Jorge Ederson Gonçalves Santana, Cícera Datiane de Morais Oliveira-Tintino, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Daniel Sampaio Alves, Talysson Felismino Moura, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, João Pedro Viana Rodrigues, Vanessa Barbosa Pinheiro Gonçalves, Robert |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |