Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like protein 13B Labeling in Axon Initial Segment
Jacques Gilloteaux, Kathleen De Swert, Valérie Suain, Charles Nicaise, Antonietta Bernardo · 2023
Read Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like protein 13B Labeling in Axon Initial Segment by Jacques Gilloteaux, Kathleen De Swert, Valérie Suain, Charles Nicaise, Antonietta Bernardo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10671465.txt.
Description
Jacques Gilloteaux and colleagues watch thalamic nerve cells survive a brain injury that strips their insulation, in a mouse model of osmotic demyelination syndrome. The model swings blood sodium low, then restores it fast, damaging two thalamic relay nuclei without immune attack. Tissue was checked hours after the sodium fix.
Some neurons at the damage edge grew out their primary cilium and axon starting zone, marked by a protein called ARL13B in rod shapes. The marked length grew with distance from the damage core and with time. Fine structure showed busy protein-making zones and energy-hungry transport. The signs sketch how these neurons begin to heal.
Catalog record
| CREATOR | Jacques Gilloteaux, Kathleen De Swert, Valérie Suain, Charles Nicaise, Antonietta Bernardo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |