Conformational States of the CXCR4 Inhibitor Peptide EPI-X4—A Theoretical Analysis
Christoph Karsten Jung, Jan Münch, Timo Jacob, Anastasios Lymperopoulos · 2023
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Description
EPI-X4, an endogenous peptide inhibitor, has exhibited potential as a blocker of CXCR4—a G protein-coupled receptor. This unique inhibitor demonstrates the ability to impede HIV-1 infection and halt CXCR4-dependent processes such as tumor cell migration and invagination. Despite its promising effects, a comprehensive understanding of the interaction between EPI-X4 and CXCR4 under natural conditions remains elusive due to experimental limitations.
Catalog record
| CREATOR | Christoph Karsten Jung, Jan Münch, Timo Jacob, Anastasios Lymperopoulos |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |