Alkyl Derivatives of Perylene Photosensitizing Antivirals: Towards Understanding the Influence of Lipophilicity
Igor E. Mikhnovets, Jiří Holoubek, Irina S. Panina, Jan Kotouček, Daniil A. Gvozdev, Stepan P. Chumakov, Maxim S. Krasilnikov, Mikhail Y. Zhitlov, Evgeny L. Gulyak, Alexey A. Chistov, Timofei D. Nikitin, Vladimir A. Korshun, Roman G. Efremov, Vera A. Alferova, Daniel Růžek, Luděk Eyer, Alexey V. Ust · 2023
Read Alkyl Derivatives of Perylene Photosensitizing Antivirals: Towards Understanding the Influence of Lipophilicity by Igor E. Mikhnovets, Jiří Holoubek, Irina S. Panina, Jan Kotouček, Daniil A. Gvozdev, Stepan P. Chumakov, Maxim S. Krasilnikov, Mikhail Y. Zhitlov, Evgeny L. Gulyak, Alexey A. Chistov, Timofei D. Nikitin, Vladimir A. Korshun, Roman G. Efremov, Vera A. Alferova, Daniel Růžek, Luděk Eyer, Alexey V. Ust (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10671050.txt.
Description
Igor Mikhnovets and co-authors present a 2023 study on light-activated compounds that attack viruses. The compounds latch onto the fatty shell of a virus and, under light, release a reactive form of oxygen that damages the shell. Past work varied the water-loving part of the molecule; this study varies the fat-loving part.
The team attached carbon chains of three lengths to the core ring and built a set of variants from them. Each variant was checked as a light emitter and oxygen maker, then tested against herpes and other viruses. The goal is to learn how fat-loving strength tunes virus killing, to guide better designs.
Catalog record
| CREATOR | Igor E. Mikhnovets, Jiří Holoubek, Irina S. Panina, Jan Kotouček, Daniil A. Gvozdev, Stepan P. Chumakov, Maxim S. Krasilnikov, Mikhail Y. Zhitlov, Evgeny L. Gulyak, Alexey A. Chistov, Timofei D. Nikitin, Vladimir A. Korshun, Roman G. Efremov, Vera A. Alferova, Daniel Růžek, Luděk Eyer, Alexey V. Ust |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |