A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma
Leonard Kaps, Adrian Klefenz, Henry Traenckner, Paul Schneider, Ion Andronache, Rainer Schobert, Bernhard Biersack, Detlef Schuppan, Cynthia Simbulan-Rosenthal · 2023
Read A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma by Leonard Kaps, Adrian Klefenz, Henry Traenckner, Paul Schneider, Ion Andronache, Rainer Schobert, Bernhard Biersack, Detlef Schuppan, Cynthia Simbulan-Rosenthal (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10670708.txt.
Description
Aim: The semisynthetic derivatives MePip-SF5 and isogarcinol, which are aligned with the natural products curcumin and garcinol, were tested for their antitumor effects in a preclinical model of pulmonary melanoma metastasis. Methods and results: MePip-SF5 was almost five times more effective in inhibiting B16F10 melanoma cell proliferation than its original substance of curcumin (IC50 MePip-SF5 2.8 vs. 13.8 µM).
Catalog record
| CREATOR | Leonard Kaps, Adrian Klefenz, Henry Traenckner, Paul Schneider, Ion Andronache, Rainer Schobert, Bernhard Biersack, Detlef Schuppan, Cynthia Simbulan-Rosenthal |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |