Assessment of Fallopian Tube Epithelium Features Derived from Induced Pluripotent Stem Cells of Both Fallopian Tube and Skin Origins
Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding, Christoffel Arnold Spek · 2023
Read Assessment of Fallopian Tube Epithelium Features Derived from Induced Pluripotent Stem Cells of Both Fallopian Tube and Skin Origins by Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding, Christoffel Arnold Spek (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10670511.txt.
Description
Yu-Hsun Chang and co-authors grow fallopian tube lining cells from reprogrammed stem cells in this 2023 study. Those lining cells matter because a deadly ovarian cancer appears to start in them, yet they are hard to keep for lab work.
The team turned fallopian tube cells into induced pluripotent stem cells using a four factor virus system. The stem cells proved able to form all three germ layers in dish tests and in tumors grown in mice. Guided by signals including a growth factor called WNT3A, they then matured into tube lining cells with the right markers and tube like shapes. Tube sourced stem cells matched skin sourced ones in this power, opening a clean route to model the disease.
Catalog record
| CREATOR | Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding, Christoffel Arnold Spek |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |