Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation
Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu, Andrew Clarkson · 2023
Read Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation by Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu, Andrew Clarkson (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10670437.txt.
Description
Ziyang Chen and colleagues present a two thousand twenty-three mouse study linking early-life separation to adult gut pain through brain mast cells. Separating newborns from mothers produced lasting visceral hypersensitivity. Whether immune mast cells in a stress hub of the brain drive that pain was unknown.
Separated mice grew into adults with lowered pain thresholds and stronger reflexes. Mast cells and stress-hormone neurons in the hypothalamus switched on together. Histamine from mast cells rose, and its receptors multiplied on the neurons. Stabilizing mast cells calmed the neurons and the pain, while histamine did the opposite, proving the chain.
Catalog record
| CREATOR | Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu, Andrew Clarkson |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |