Prognostic Impact of Copy Number Alterations’ Profile and AID/RAG Signatures in Acute Lymphoblastic Leukemia (ALL) with BCR::ABL and without Recurrent Genetic Aberrations (NEG ALL) Treated with Intensive Chemotherapy
Marta Libura, Karolina Karabin, Paweł Tyrna, Anna Czyż, Hanna Makuch-Łasica, Bożena Jaźwiec, Monika Paluszewska, Beata Piątkowska-Jakubas, Magdalena Zawada, Michał Gniot, Joanna Trubicka, Magdalena Szymańska, Katarzyna Borg, Marta Więsik, Sylwia Czekalska, Izabela Florek, Maria Król, Małgorzata Pasz · 2023
Read Prognostic Impact of Copy Number Alterations’ Profile and AID/RAG Signatures in Acute Lymphoblastic Leukemia (ALL) with BCR::ABL and without Recurrent Genetic Aberrations (NEG ALL) Treated with Intensive Chemotherapy by Marta Libura, Karolina Karabin, Paweł Tyrna, Anna Czyż, Hanna Makuch-Łasica, Bożena Jaźwiec, Monika Paluszewska, Beata Piątkowska-Jakubas, Magdalena Zawada, Michał Gniot, Joanna Trubicka, Magdalena Szymańska, Katarzyna Borg, Marta Więsik, Sylwia Czekalska, Izabela Florek, Maria Król, Małgorzata Pasz (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10670434.txt.
Description
A peer-reviewed research article from Europe PMC (2023). Simple SummaryAdult ALL is a highly aggressive blood cancer. Two classes of genetic aberrations are responsible for ALL: primary aberrations followed by secondary aberrations. Currently, primary aberrations are used for estimating patients’ risk in adult ALL. In this study, we reassessed the importance of primary and secondary copy number alterations (CNA) aberrations in intensively treated adult ALL patients in correlation to RAG/AID mutator enzyme expression. Primary aberrations alone specified the risk of 30% of patients.
Catalog record
| CREATOR | Marta Libura, Karolina Karabin, Paweł Tyrna, Anna Czyż, Hanna Makuch-Łasica, Bożena Jaźwiec, Monika Paluszewska, Beata Piątkowska-Jakubas, Magdalena Zawada, Michał Gniot, Joanna Trubicka, Magdalena Szymańska, Katarzyna Borg, Marta Więsik, Sylwia Czekalska, Izabela Florek, Maria Król, Małgorzata Pasz |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |