A High-Throughput, High-Containment Human Primary Epithelial Airway Organ-on-Chip Platform for SARS-CoV-2 Therapeutic Screening
Christine R. Fisher, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Thomas J. Mulhern, Caitlin R. Miller, Chelsea J. Zhang, Logan D. Rubio, Elizabeth E. Marr, Vidhya Vijayakumar, Elizabeth P. Gabriel, Landys Lopez Quezada, Chun-Hui Zhang, Karen S. Anderson, William L. Jorgensen, Jehan W. Allad · 2023
Read A High-Throughput, High-Containment Human Primary Epithelial Airway Organ-on-Chip Platform for SARS-CoV-2 Therapeutic Screening by Christine R. Fisher, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Thomas J. Mulhern, Caitlin R. Miller, Chelsea J. Zhang, Logan D. Rubio, Elizabeth E. Marr, Vidhya Vijayakumar, Elizabeth P. Gabriel, Landys Lopez Quezada, Chun-Hui Zhang, Karen S. Anderson, William L. Jorgensen, Jehan W. Allad (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10669988.txt.
Description
Christine Fisher and co-authors build, in a 2023 study, a chip-based airway model that can screen drugs against the COVID virus in high containment. Drug hunts for the virus lagged vaccine work, in part for lack of human-like test models that can hold the live virus at scale. Their platform grows real human airway cells on chips, 96 to a plate. The virus grew well in the chips and spread in a steady way over six days. Lung tissue from three donors each gave its own growth curve shape.
Light stains, gene tests, and plaque counts tracked the infection in each donor set. Two drugs, remdesivir and a second candidate, both cut virus growth in the chips. The plate-scale form lets labs screen many drugs at once in a human-like airway.
Catalog record
| CREATOR | Christine R. Fisher, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Thomas J. Mulhern, Caitlin R. Miller, Chelsea J. Zhang, Logan D. Rubio, Elizabeth E. Marr, Vidhya Vijayakumar, Elizabeth P. Gabriel, Landys Lopez Quezada, Chun-Hui Zhang, Karen S. Anderson, William L. Jorgensen, Jehan W. Allad |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |