Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions
Nada Lukkahatai, Jongmin Park, Hejingzi Monica Jia, Daniel Martin, Junxin Li, Jennifer Yeong-Shin Sheng, Jessica Gill, Leorey N Saligan, Vered Stearns, Michael Carducci, Bo-Ying Bao · 2023
Read Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions by Nada Lukkahatai, Jongmin Park, Hejingzi Monica Jia, Daniel Martin, Junxin Li, Jennifer Yeong-Shin Sheng, Jessica Gill, Leorey N Saligan, Vered Stearns, Michael Carducci, Bo-Ying Bao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10669866.txt.
Description
Cancer survivors who live with several chronic diseases often fight fatigue and low mood, and doctors lack a simple blood sign of how they are coping. Nada Lukkahatai and co-authors test DNA methylation age, a clock read from chemical marks on DNA, as such a sign. Their 2023 pilot drew ten people from a larger trial of an exercise programme.
After the programme, the exercise group tended to show a small drop in methylation age and in age acceleration, the gap between the clock and real age. Changes in the clock also tracked changes in resilience scores: as one fell, the other rose. The authors stress the tiny sample and call the work a feasibility check, with a larger study needed before the clock can guide care. Still, the hint that exercise can move the clock is worth chasing.
Catalog record
| CREATOR | Nada Lukkahatai, Jongmin Park, Hejingzi Monica Jia, Daniel Martin, Junxin Li, Jennifer Yeong-Shin Sheng, Jessica Gill, Leorey N Saligan, Vered Stearns, Michael Carducci, Bo-Ying Bao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |