Glutamine-rich regions of the disordered CREB transactivation domain mediate dynamic intra- and intermolecular interactions
Maria A. Martinez-Yamout, Irem Nasir, Sergey Shnitkind, Jamie P. Ellis, Rebecca B. Berlow, Gerard Kroon, Ashok A. Deniz, H. Jane Dyson, Peter E. Wright · 2023
Read Glutamine-rich regions of the disordered CREB transactivation domain mediate dynamic intra- and intermolecular interactions by Maria A. Martinez-Yamout, Irem Nasir, Sergey Shnitkind, Jamie P. Ellis, Rebecca B. Berlow, Gerard Kroon, Ashok A. Deniz, H. Jane Dyson, Peter E. Wright (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10666024.txt.
Description
SignificanceThe CREB (cyclic AMP response element binding protein) transcription factor contains a large N-terminal transactivation domain comprising a kinase inducible activation domain and two glutamine-rich regions. Here, we use complementary biophysical methods to show that the transactivation domain is intrinsically disordered and largely extended but exhibits local preferences for secondary structure.
Catalog record
| CREATOR | Maria A. Martinez-Yamout, Irem Nasir, Sergey Shnitkind, Jamie P. Ellis, Rebecca B. Berlow, Gerard Kroon, Ashok A. Deniz, H. Jane Dyson, Peter E. Wright |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |