Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group
Tanya Román, Gerardo Acosta, Constanza Cárdenas, Beatriz G de la Torre, Fanny Guzmán, Fernando Albericio, Philip Hublitz · 2023
Read Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group by Tanya Román, Gerardo Acosta, Constanza Cárdenas, Beatriz G de la Torre, Fanny Guzmán, Fernando Albericio, Philip Hublitz (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10660853.txt.
Description
A peer-reviewed research article from Europe PMC (2023). One approach to enhance the bioavailability and half-life of peptides in vivo is through N-methylation of one or more of the amino acids within the peptide sequence. However, commercially available Fmoc-N-Me-AA-OHs are limited and often expensive. In this study, a solid-phase synthesis method for Fmoc-N-Me-AA-OH was developed using a 2-chlorotrityl chloride (2-CTC) resin as a temporary protective group for the carboxylic acid strategy. Two strategies for the alkylation step were compared, employing either dimethyl sulfate or methyl iodide in the Biron−Kessler method.
Catalog record
| CREATOR | Tanya Román, Gerardo Acosta, Constanza Cárdenas, Beatriz G de la Torre, Fanny Guzmán, Fernando Albericio, Philip Hublitz |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |