Effects of MAP4K inhibition on neurite outgrowth
Di Ja Lasham, Reza K Arta, Abdul Fuad Hadi, Jun Egawa, Vance P Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya · 2023
Read Effects of MAP4K inhibition on neurite outgrowth by Di Ja Lasham, Reza K Arta, Abdul Fuad Hadi, Jun Egawa, Vance P Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10656890.txt.
Description
Di Ja Lasham and seven co-authors switch off a family of signaling enzymes and watch young neurons shrink their reach in a 2023 study. The MAP4K enzymes pass messages inside cells and were suspects in guiding how nerve fibers grow and connect. A selective blocker let the team ask directly.
Treated neurons in dishes grew shorter fibers, though their connection points held steady. Two marker proteins tied to growth lost their activating tags in step. The authors read this as proof the enzymes are working parts of normal neuronal development. Since faltering fiber growth shadows several psychiatric disorders, the pathway earns a place on the suspect list.
Catalog record
| CREATOR | Di Ja Lasham, Reza K Arta, Abdul Fuad Hadi, Jun Egawa, Vance P Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |