Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma
Ting Tang, Hui Liang, Wuting Wei, Yanling Han, Liang Cao, Zixiang Cong, Shiqiao Luo, Handong Wang, Meng-Liang Zhou · 2023
Read Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma by Ting Tang, Hui Liang, Wuting Wei, Yanling Han, Liang Cao, Zixiang Cong, Shiqiao Luo, Handong Wang, Meng-Liang Zhou (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10656413.txt.
Description
Ting Tang and co-authors show how a plant compound kills brain tumor cells, in a 2023 study. Glioblastoma is a fierce brain cancer that shrugs off most chemotherapy. The compound, aloperine, comes from a traditional medicinal plant and had shown anti-tumor promise. Its effect on glioblastoma was untested.
In dishes, aloperine halted tumor cell growth by freezing their cycle and triggering programmed death. Tagged compound let the team watch it home in on lysosomes, the cell's waste stations. Blocking late cleanup there pushed cells into a second death mode called paraptosis. In mice with brain tumors, the compound slowed growth and teamed well with the standard drug. A new target inside the cell is the key claim.
Catalog record
| CREATOR | Ting Tang, Hui Liang, Wuting Wei, Yanling Han, Liang Cao, Zixiang Cong, Shiqiao Luo, Handong Wang, Meng-Liang Zhou |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |