Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice
Xue-Bing Bai, Shuo Xu, Lu-Jun Zhou, Xiao-Qian Meng, Yu-Lin Li, Yan-Lin Chen, Yi-Han Jiang, Wen-Zhen Lin, Bo-Yan Chen, Lin-Juan Du, Guo-Cai Tian, Yan Liu, Sheng-Zhong Duan, Ya-Qin Zhu · 2023
Read Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice by Xue-Bing Bai, Shuo Xu, Lu-Jun Zhou, Xiao-Qian Meng, Yu-Lin Li, Yan-Lin Chen, Yi-Han Jiang, Wen-Zhen Lin, Bo-Yan Chen, Lin-Juan Du, Guo-Cai Tian, Yan Liu, Sheng-Zhong Duan, Ya-Qin Zhu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10655362.txt.
Description
Xue-Bing Bai and co-authors show that gum disease bacteria can worsen Parkinson disease in mice, in a 2023 study. Gum infection had been linked to Parkinson disease before, but direct proof was lacking. The team induced gum disease with mouth bacteria in mice already given a drug that models Parkinson disease.
Mice with both conditions moved worse, lost more brain cells that make dopamine, and showed more brain inflammation. Gene checks found two oral bacteria had spread to the gut. Giving those two bacteria alone, in the setting of gum disease, reproduced the harm. They activated brain immune cells and drew a type of helper T cell into the brain and gut. Blocking a signal from those T cells protected the dopamine cells. The authors trace a mouth-to-gut-to-brain path for the effect.
Catalog record
| CREATOR | Xue-Bing Bai, Shuo Xu, Lu-Jun Zhou, Xiao-Qian Meng, Yu-Lin Li, Yan-Lin Chen, Yi-Han Jiang, Wen-Zhen Lin, Bo-Yan Chen, Lin-Juan Du, Guo-Cai Tian, Yan Liu, Sheng-Zhong Duan, Ya-Qin Zhu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |