Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
Rachel Z Blumhagen, Jonathan S Kurche, Carlyne D Cool, Avram D Walts, David Heinz, Tasha E Fingerlin, Ivana V Yang, David A Schwartz · 2023
Read Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis by Rachel Z Blumhagen, Jonathan S Kurche, Carlyne D Cool, Avram D Walts, David Heinz, Tasha E Fingerlin, Ivana V Yang, David A Schwartz (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10655274.txt.
Description
Rachel Blumhagen and co-authors map gene activity across the zones of scarred lungs in pulmonary fibrosis. The disease mixes normal tissue, active scarring fronts, and dense scar in one organ. Spatial profiling read gene use in 231 regions from thirty-two patients and twelve controls. Even normal-looking lung in patients differed from true control tissue.
Two hundred fifty-four genes split those look-alike regions apart. Stress and translation paths, including the EIF2 route, stood out there. Active fronts and dense scar shared stress activation with wound healing switched off. Air sac cell signals faded while secretory markers rose. The maps nominate fresh targets where scarring begins.
Catalog record
| CREATOR | Rachel Z Blumhagen, Jonathan S Kurche, Carlyne D Cool, Avram D Walts, David Heinz, Tasha E Fingerlin, Ivana V Yang, David A Schwartz |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |