Development of a cationic polyethyleneimine-poly(lactic-co-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics†
Shannon R. Tracey, Peter Smyth, Una M. Herron, James F. Burrows, Andrew J. Porter, Caroline J. Barelle, Christopher J. Scott · 2023
Read Development of a cationic polyethyleneimine-poly(lactic-co-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics† by Shannon R. Tracey, Peter Smyth, Una M. Herron, James F. Burrows, Andrew J. Porter, Caroline J. Barelle, Christopher J. Scott (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10654694.txt.
Description
Shannon Tracey and co-authors present in a 2023 paper how proteins can be carried into cells by a charged nanoparticle blend. Getting proteins, peptides, and other biologics inside cells could open targets once thought out of reach for drugs. Delivery inside cells stays hard, though, since large molecules cross cell walls poorly on their own and often break down before they can act.
Their system blends polyethyleneimine with a biodegradable polyester to form cationic particles, ones with a positive charge. The charged particles showed stronger uptake by cells than particles with a negative charge or none. They carried a class of small binding proteins, called vNARs, packed inside the particle core, into the cell interior. Those cargo proteins were picked for their standout stability. A tuned blend with ten percent of the charged polymer is reported.
Catalog record
| CREATOR | Shannon R. Tracey, Peter Smyth, Una M. Herron, James F. Burrows, Andrew J. Porter, Caroline J. Barelle, Christopher J. Scott |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |