Transcriptome profiles of Streptomyces clavuligerus strains producing different titers of clavulanic acid
Junpyo Gong, Jeong Sang Yi, Hang Su Cho, Chang Hun Shin, Hyung-Jin Won, Byung-Kwan Cho, Minsoo Noh, Yeo Joon Yoon · 2023
Read Transcriptome profiles of Streptomyces clavuligerus strains producing different titers of clavulanic acid by Junpyo Gong, Jeong Sang Yi, Hang Su Cho, Chang Hun Shin, Hyung-Jin Won, Byung-Kwan Cho, Minsoo Noh, Yeo Joon Yoon (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10654394.txt.
Description
Junpyo Gong and seven co-authors publish gene activity profiles for a bacterium that makes a valuable antibiotic helper, in a data paper from 2023. The bacterium produces clavulanic acid, a drug that shields antibiotics from bacterial defenses. Industry uses this strain widely, and mutants of it make more, less, or none of the compound.
The team sequenced RNA from the wild strain and three mutants at four growth stages. All thirty-two samples passed quality checks with high scores. Comparing profiles across strains with different yields can reveal which genes drive production. The authors offer the data as a resource for engineering better industrial strains.
Catalog record
| CREATOR | Junpyo Gong, Jeong Sang Yi, Hang Su Cho, Chang Hun Shin, Hyung-Jin Won, Byung-Kwan Cho, Minsoo Noh, Yeo Joon Yoon |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |