Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal
Sebastian Schruefer, Annica Pschibul, Sarah Sze Wah Wong, Tongta Sae-Ong, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Axel A Brakhage, Vishukumar Aimanianda, Olaf Kniemeyer, Frank Ebel · 2023
Read Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal by Sebastian Schruefer, Annica Pschibul, Sarah Sze Wah Wong, Tongta Sae-Ong, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Axel A Brakhage, Vishukumar Aimanianda, Olaf Kniemeyer, Frank Ebel (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10647056.txt.
Description
BackgroundAspergillus fumigatus is a major fungal pathogen that causes severe problems due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that triggers a lethal activation of the fungal-specific High Osmolarity Glycerol pathway. Its pronounced antifungal activity against A. fumigatus and other pathogenic molds renders this agent an attractive lead substance for the development of new therapeutics.
Catalog record
| CREATOR | Sebastian Schruefer, Annica Pschibul, Sarah Sze Wah Wong, Tongta Sae-Ong, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Axel A Brakhage, Vishukumar Aimanianda, Olaf Kniemeyer, Frank Ebel |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |