The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury
Yingyan Chen, Leilei Ai, Yingyi Zhang, Xiang Li, Shiqian Xu, Weijie Yang, Jiamin Jin, Yerong Ma, Zhanhong Hu, Yinli Zhang, Yan Rong, Songying Zhang · 2023
Read The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury by Yingyan Chen, Leilei Ai, Yingyi Zhang, Xiang Li, Shiqian Xu, Weijie Yang, Jiamin Jin, Yerong Ma, Zhanhong Hu, Yinli Zhang, Yan Rong, Songying Zhang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10646043.txt.
Description
A peer-reviewed research article from Europe PMC (2023). Chemotherapy-induced ovarian damage and infertility are significant concerns for women of childbearing age with cancer; however, the underlying mechanisms are still not fully understood. Our study has revealed a close association between epigenetic regulation and cyclophosphamide (CTX)-induced ovarian damage. Specifically, CTX and its active metabolite 4-hydroperoxy cyclophosphamide (4-HC) were found to increase the apoptosis of granulosa cells (GCs) by reducing EZH2 and H3K27me3 levels, both in vivo and in vitro.
Catalog record
| CREATOR | Yingyan Chen, Leilei Ai, Yingyi Zhang, Xiang Li, Shiqian Xu, Weijie Yang, Jiamin Jin, Yerong Ma, Zhanhong Hu, Yinli Zhang, Yan Rong, Songying Zhang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |