The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes
Collin Matsumoto, Samantha C O’Dwyer, Declan Manning, Gonzalo Hernandez-Hernandez, Paula Rhana, Zhihui Fong, Daisuke Sato, Colleen E Clancy, Nicholas C Vierra, James S Trimmer, L Fernando Santana · 2023
Read The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes by Collin Matsumoto, Samantha C O’Dwyer, Declan Manning, Gonzalo Hernandez-Hernandez, Paula Rhana, Zhihui Fong, Daisuke Sato, Colleen E Clancy, Nicholas C Vierra, James S Trimmer, L Fernando Santana (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10645748.txt.
Description
In arterial myocytes, the canonical function of voltage-gated CaV1.2 and KV2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively. Paradoxically, KV2.1 also plays a sex-specific role by promoting the clustering and activity of CaV1.2 channels. However, the impact of KV2.1 protein organization on CaV1.2 function remains poorly understood. We discovered that KV2.
Catalog record
| CREATOR | Collin Matsumoto, Samantha C O’Dwyer, Declan Manning, Gonzalo Hernandez-Hernandez, Paula Rhana, Zhihui Fong, Daisuke Sato, Colleen E Clancy, Nicholas C Vierra, James S Trimmer, L Fernando Santana |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |