Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
Andrew A Welch, Rahele A Farahani, Aoife M Egan, Marcello C Laurenti, Maya Zeini, Max Vella, Kent R Bailey, Claudio Cobelli, Chiara Dalla Man, Aleksey Matveyenko, Adrian Vella · 2023
Read Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans by Andrew A Welch, Rahele A Farahani, Aoife M Egan, Marcello C Laurenti, Maya Zeini, Max Vella, Kent R Bailey, Claudio Cobelli, Chiara Dalla Man, Aleksey Matveyenko, Adrian Vella (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10645389.txt.
Description
BACKGROUNDProglucagon can be processed to glucagon-like peptide1 (GLP-1) within the islet, but its contribution to islet function in humans remains unknown. We sought to understand whether pancreatic GLP-1 alters islet function in humans and whether this is affected by type 2 diabetes.METHODSWe therefore studied individuals with and without type 2 diabetes on two occasions in random order.
Catalog record
| CREATOR | Andrew A Welch, Rahele A Farahani, Aoife M Egan, Marcello C Laurenti, Maya Zeini, Max Vella, Kent R Bailey, Claudio Cobelli, Chiara Dalla Man, Aleksey Matveyenko, Adrian Vella |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |