Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus
Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo · 2023
Read Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus by Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10498813.txt.
Description
Chan Li and six co-authors present a study from twenty twenty-three on a ginseng compound that fights morphine reward in mice, and a tiny RNA that can undo it. Morphine addiction links to a skewed gut flora. A gut germ, Bacteroides vulgatus, boosts the ginseng compound's help. The team tracks a stool microRNA that morphine raises and the compound lowers.
That RNA curbs the germ's growth by a hit on one of its genes. It also shifts two chemical outputs in lab tests. Fed to mice, the RNA raised a brain chemical in the hippocampus and blocked the compound's gains: germ counts fell back and morphine reward returned. The team casts the RNA as a brake on the gut route to addiction relief.
Catalog record
| CREATOR | Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |