Integrated in silico and in vivo larvicidal evaluation of compounds targeting juvenile hormone for malaria vector control
Eric Kibagendi Osoro, Adeniyi Ayinde Abdulwahab, Florence Ezinwa Nkemehule, Adedoyin John-Joy Owolade, Micheal Abimbola Oladosu, Wilberforce K Ndarawit, Daramola Oluwasegun Oluwatobiloba, Moses Adondua Abah · 2026
Read Integrated in silico and in vivo larvicidal evaluation of compounds targeting juvenile hormone for malaria vector control by Eric Kibagendi Osoro, Adeniyi Ayinde Abdulwahab, Florence Ezinwa Nkemehule, Adedoyin John-Joy Owolade, Micheal Abimbola Oladosu, Wilberforce K Ndarawit, Daramola Oluwasegun Oluwatobiloba, Moses Adondua Abah (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0352147.txt.
Description
Eric Osoro and seven colleagues screen thousands of compounds for a kinder way to kill malaria mosquitoes. Their 2026 study targets the mosquito's juvenile hormone system. Blocking the protein that carries this hormone can derail mosquito development. The team virtually screened nearly twenty-nine hundred agrochemical compounds on the computer. Docking tests ranked how tightly each gripped the target protein. Energy calculations, chemistry checks, and toxicity predictions narrowed the list further. Fifteen lead compounds survived.
The best of them bound as strongly as the natural reference compound in simulations. Long dynamics runs tested whether those grips held over time. Electronic structure analysis favoured the same shortlist. The study pairs this computing with laboratory larvicide evaluation, per its design. Mosquito control leans heavily on a few insecticides, and resistance keeps growing. Hormone-targeted candidates, screened early for environmental safety, widen the arsenal before field resistance closes the current one.
Catalog record
| CREATOR | Eric Kibagendi Osoro, Adeniyi Ayinde Abdulwahab, Florence Ezinwa Nkemehule, Adedoyin John-Joy Owolade, Micheal Abimbola Oladosu, Wilberforce K Ndarawit, Daramola Oluwasegun Oluwatobiloba, Moses Adondua Abah |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67806 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |