Study on the pathogenesis of PLXNB1 gene in olfactory dysfunction of allergic rhinitis
Xinglong Chen, Lingqiong Zhao, Wenlong Luo · 2026
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Description
Xinglong Chen, Lingqiong Zhao, and Wenlong Luo studied a gene called PLXNB1 in allergic rhinitis smell loss in 2026. Many hay fever patients lose smell, and inflammation alone does not explain the molecular chain behind it.
Public data sets showed the gene running low in patients. Its level moved against inflammatory immune cell levels. In nasal cells and a mouse model, silencing the gene raised inflammatory signals through a known stress pathway, while restoring it, or a common allergy drug, calmed them. The gene emerges as a possible hub tying immune imbalance to smell loss, and a candidate drug target.
Catalog record
| CREATOR | Xinglong Chen, Lingqiong Zhao, Wenlong Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38889 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |