Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease
Alexandra Gaál Kovalčíková, Gabriela Forraiová, Nelia Korotushak, Veronika Borbélyová, Diana Vavrincová-Yaghi, Peter Vavrinec, Ľudmila Podracká, Peter Celec · 2026
Read Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease by Alexandra Gaál Kovalčíková, Gabriela Forraiová, Nelia Korotushak, Veronika Borbélyová, Diana Vavrincová-Yaghi, Peter Vavrinec, Ľudmila Podracká, Peter Celec (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0350004.txt.
Description
Alexandra Gaal Kovalcikova and colleagues tested whether white cell nets drive kidney damage in a mouse model of chronic kidney disease. Nets are webs of DNA that immune cells cast out, suspected of harming tissue. Mice lacking the enzyme that enables net making were compared with normal mice, both dosed with a kidney harming chemical for two weeks.
Chemical dosing shrank body weight and worsened kidney markers sharply in normal mice. Knockout mice fared no better, and even showed an earlier rise in one kidney marker. Immune cells were clearly activated, yet net making itself did not drive damage in this model. Kidney researchers should look elsewhere for this models main harm path.
Catalog record
| CREATOR | Alexandra Gaál Kovalčíková, Gabriela Forraiová, Nelia Korotushak, Veronika Borbélyová, Diana Vavrincová-Yaghi, Peter Vavrinec, Ľudmila Podracká, Peter Celec |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43243 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |