Change in plasma cryptococcal antigen titers in Uganda among outpatients with advanced HIV disease from 2017 to 2022 with rollout of national cryptococcal screening

Alexandra Poeschla, Abduljewad Wele, Elizabeth Nalintya, Biyue Dai, David B Meya, David R Boulware, Radha Rajasingham · 2026

Read Change in plasma cryptococcal antigen titers in Uganda among outpatients with advanced HIV disease from 2017 to 2022 with rollout of national cryptococcal screening by Alexandra Poeschla, Abduljewad Wele, Elizabeth Nalintya, Biyue Dai, David B Meya, David R Boulware, Radha Rajasingham (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0349854.txt.

Description

Alexandra Poeschla and co-authors tracked a fungal infection marker in Ugandan outpatients with advanced HIV from 2017 to 2022 in work published in 2026. Cryptococcal disease kills many such patients, and a blood antigen test can catch it before symptoms, as national screening expanded.

More than four hundred adults tested positive. Their immune counts were very low, and the median marker level sat at a mid range tied to risk. Over the years the share already on HIV treatment at screening fell, while marker levels drifted up without a clear trend. The data show screening reaching people later, a gap programs must close.

Catalog record

CREATORAlexandra Poeschla, Abduljewad Wele, Elizabeth Nalintya, Biyue Dai, David B Meya, David R Boulware, Radha Rajasingham
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE16414
LICENSECC_BY
RIGHTSCC BY
SOURCEPLOS

Source: https://doi.org/10.1371/journal.pone.0349854

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