Solution structure of mouse HBS1L/SKI7-specific UBA domain in complex with ubiquitin: Implications for stalled ribosome recognition
Nobukazu Nameki, Fahu He, Minako Okada, Mari Takahashi, Kengo Tsuda, Takashi Nagata, Peter Güntert, Naohiro Kobayashi · 2026
Read Solution structure of mouse HBS1L/SKI7-specific UBA domain in complex with ubiquitin: Implications for stalled ribosome recognition by Nobukazu Nameki, Fahu He, Minako Okada, Mari Takahashi, Kengo Tsuda, Takashi Nagata, Peter Güntert, Naohiro Kobayashi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0348877.txt.
Description
Nobukazu Nameki and co-authors solved the structure of a mouse protein piece bound to ubiquitin in 2026. The piece comes from proteins that help clear ribosomes stuck on faulty messages, a cleanup job vital to healthy cells, but its grip on ubiquitin was only guessed.
Using nuclear magnetic resonance, the team mapped the three helix bundle and its contact with ubiquitin's sticky patch, finding a grip much like that of known ubiquitin readers. One loop, though, had a distinctive double turn found in no close cousin. The detail refines ideas about how stuck ribosome cleanup crews recognise their targets.
Catalog record
| CREATOR | Nobukazu Nameki, Fahu He, Minako Okada, Mari Takahashi, Kengo Tsuda, Takashi Nagata, Peter Güntert, Naohiro Kobayashi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55839 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |